Effect of pulsatile administration of levodopa on dyskinesia induction in drug‐naïve MPTP‐treated common marmosets: Effect of dose, frequency of administration, and brain exposure
Identifieur interne : 004108 ( Main/Exploration ); précédent : 004107; suivant : 004109Effect of pulsatile administration of levodopa on dyskinesia induction in drug‐naïve MPTP‐treated common marmosets: Effect of dose, frequency of administration, and brain exposure
Auteurs : Lance A. Smith [Royaume-Uni] ; Michael J. Jackson [Royaume-Uni] ; Matthew J. Hansard [Royaume-Uni] ; Eleni Maratos [Royaume-Uni] ; Peter Jenner [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-05.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (adverse effects), Animal, Animals, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (metabolism), Antiparkinson Agents (pharmacology), Antiparkinson agent, Callithrix, Carbidopa (administration & dosage), Carbidopa (metabolism), Carbidopa (pharmacology), Catechols (administration & dosage), Catechols (pharmacology), Chemotherapy, Dose, Dose-Response Relationship, Drug, Drug Synergism, Drug Therapy, Combination, Dyskinesia, Dyskinesia, Drug-Induced (etiology), Dyskinesia, Drug-Induced (prevention & control), Experimental disease, Female, Levodopa, Levodopa (administration & dosage), Levodopa (metabolism), Levodopa (pharmacology), Locomotion (drug effects), L‐dopa, MPTP, Male, Nitriles, Parkinson disease, Parkinsonian Disorders (prevention & control), Posology, Primates, Pulse Therapy, Drug (methods), Substantia Nigra (drug effects), Time Factors, Treatment efficiency, dyskinesia, entacapone, primates.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Carbidopa, Catechols, Levodopa.
- chemical , adverse effects : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- chemical , metabolism : Antiparkinson Agents, Carbidopa, Levodopa.
- chemical , pharmacology : Antiparkinson Agents, Carbidopa, Catechols, Levodopa.
- drug effects : Locomotion, Substantia Nigra.
- etiology : Dyskinesia, Drug-Induced.
- methods : Pulse Therapy, Drug.
- prevention & control : Dyskinesia, Drug-Induced, Parkinsonian Disorders.
- Animals, Callithrix, Dose-Response Relationship, Drug, Drug Synergism, Drug Therapy, Combination, Female, Male, Nitriles, Time Factors.
Abstract
Levodopa (L‐dopa) consistently primes basal ganglia for the appearance of dyskinesia in parkinsonian patients and 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine hydrochloride (MPTP) ‐treated primates. This finding may reflect its relatively short duration of effects resulting in pulsatile stimulation of postsynaptic dopamine receptors in the striatum. We have compared the relationship between L‐dopa dose and frequency of administration on dyskinesia initiation in drug‐naïve, MPTP‐treated common marmosets. We have also studied the effect of increased brain exposure to pulsatile administration by combining a low‐dose of L‐dopa with the peripheral catechol‐O‐methyltransferase inhibitor (COMT‐I), entacapone. Pulsatile administration of a low (dose range, 5.0–7.5 mg/kg p.o.) or a high (12.5 mg/kg) dose of L‐dopa plus carbidopa b.i.d. produced a dose‐related reversal of motor deficits. Repeated administration of low and high doses of L‐dopa for 26 days to drug‐naïve, MPTP‐treated animals also caused a dose‐related induction of peak‐dose dyskinesia. Repeated administration of high‐dose L‐dopa b.i.d. compared to once daily caused a frequency‐related improvement of motor symptoms, resulting in a more rapid and initially more intense appearance of peak‐dose dyskinesia. Administration of low‐dose L‐dopa b.i.d. for 26 days in combination with entacapone enhanced the increase in locomotor activity and reversal of disability produced by L‐dopa alone, but with no obvious change in duration of L‐dopa's effect. However, combining entacapone with L‐dopa resulted in the more rapid appearance of dyskinesia, which was initially more severe than occurred with L‐dopa alone. Importantly, increasing pulsatile exposure of brain to L‐dopa by preventing its peripheral breakdown also increases dyskinesia induction. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10394
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000262
- to stream Istex, to step Curation: 000262
- to stream Istex, to step Checkpoint: 002A38
- to stream PubMed, to step Corpus: 003799
- to stream PubMed, to step Curation: 003799
- to stream PubMed, to step Checkpoint: 003796
- to stream Ncbi, to step Merge: 000A52
- to stream Ncbi, to step Curation: 000A52
- to stream Ncbi, to step Checkpoint: 000A52
- to stream Main, to step Merge: 005D31
- to stream PascalFrancis, to step Corpus: 002479
- to stream PascalFrancis, to step Curation: 000842
- to stream PascalFrancis, to step Checkpoint: 002472
- to stream Main, to step Merge: 006018
- to stream Main, to step Curation: 004108
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of pulsatile administration of levodopa on dyskinesia induction in drug‐naïve MPTP‐treated common marmosets: Effect of dose, frequency of administration, and brain exposure</title>
<author><name sortKey="Smith, Lance A" sort="Smith, Lance A" uniqKey="Smith L" first="Lance A." last="Smith">Lance A. Smith</name>
</author>
<author><name sortKey="Jackson, Michael J" sort="Jackson, Michael J" uniqKey="Jackson M" first="Michael J." last="Jackson">Michael J. Jackson</name>
</author>
<author><name sortKey="Hansard, Matthew J" sort="Hansard, Matthew J" uniqKey="Hansard M" first="Matthew J." last="Hansard">Matthew J. Hansard</name>
</author>
<author><name sortKey="Maratos, Eleni" sort="Maratos, Eleni" uniqKey="Maratos E" first="Eleni" last="Maratos">Eleni Maratos</name>
</author>
<author><name sortKey="Jenner, Peter" sort="Jenner, Peter" uniqKey="Jenner P" first="Peter" last="Jenner">Peter Jenner</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:B332C5624656CEA1219E695C498CAAE735CA56EC</idno>
<date when="2003" year="2003">2003</date>
<idno type="doi">10.1002/mds.10394</idno>
<idno type="url">https://api.istex.fr/document/B332C5624656CEA1219E695C498CAAE735CA56EC/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000262</idno>
<idno type="wicri:Area/Istex/Curation">000262</idno>
<idno type="wicri:Area/Istex/Checkpoint">002A38</idno>
<idno type="wicri:doubleKey">0885-3185:2003:Smith L:effect:of:pulsatile</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:12722161</idno>
<idno type="wicri:Area/PubMed/Corpus">003799</idno>
<idno type="wicri:Area/PubMed/Curation">003799</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003796</idno>
<idno type="wicri:Area/Ncbi/Merge">000A52</idno>
<idno type="wicri:Area/Ncbi/Curation">000A52</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000A52</idno>
<idno type="wicri:doubleKey">0885-3185:2003:Smith L:effect:of:pulsatile</idno>
<idno type="wicri:Area/Main/Merge">005D31</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:03-0379786</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002479</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000842</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002472</idno>
<idno type="wicri:doubleKey">0885-3185:2003:Smith L:effect:of:pulsatile</idno>
<idno type="wicri:Area/Main/Merge">006018</idno>
<idno type="wicri:Area/Main/Curation">004108</idno>
<idno type="wicri:Area/Main/Exploration">004108</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effect of pulsatile administration of levodopa on dyskinesia induction in drug‐naïve MPTP‐treated common marmosets: Effect of dose, frequency of administration, and brain exposure</title>
<author><name sortKey="Smith, Lance A" sort="Smith, Lance A" uniqKey="Smith L" first="Lance A." last="Smith">Lance A. Smith</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Pharmacology and Therapeutics, Guy's, King's, and St Thomas' School of Biomedical Sciences, King's College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jackson, Michael J" sort="Jackson, Michael J" uniqKey="Jackson M" first="Michael J." last="Jackson">Michael J. Jackson</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Pharmacology and Therapeutics, Guy's, King's, and St Thomas' School of Biomedical Sciences, King's College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hansard, Matthew J" sort="Hansard, Matthew J" uniqKey="Hansard M" first="Matthew J." last="Hansard">Matthew J. Hansard</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Pharmacology and Therapeutics, Guy's, King's, and St Thomas' School of Biomedical Sciences, King's College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maratos, Eleni" sort="Maratos, Eleni" uniqKey="Maratos E" first="Eleni" last="Maratos">Eleni Maratos</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Pharmacology and Therapeutics, Guy's, King's, and St Thomas' School of Biomedical Sciences, King's College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jenner, Peter" sort="Jenner, Peter" uniqKey="Jenner P" first="Peter" last="Jenner">Peter Jenner</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Pharmacology and Therapeutics, Guy's, King's, and St Thomas' School of Biomedical Sciences, King's College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2003-05">2003-05</date>
<biblScope unit="vol">18</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="487">487</biblScope>
<biblScope unit="page" to="495">495</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">B332C5624656CEA1219E695C498CAAE735CA56EC</idno>
<idno type="DOI">10.1002/mds.10394</idno>
<idno type="ArticleID">MDS10394</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (adverse effects)</term>
<term>Animal</term>
<term>Animals</term>
<term>Antiparkinson Agents (administration & dosage)</term>
<term>Antiparkinson Agents (metabolism)</term>
<term>Antiparkinson Agents (pharmacology)</term>
<term>Antiparkinson agent</term>
<term>Callithrix</term>
<term>Carbidopa (administration & dosage)</term>
<term>Carbidopa (metabolism)</term>
<term>Carbidopa (pharmacology)</term>
<term>Catechols (administration & dosage)</term>
<term>Catechols (pharmacology)</term>
<term>Chemotherapy</term>
<term>Dose</term>
<term>Dose-Response Relationship, Drug</term>
<term>Drug Synergism</term>
<term>Drug Therapy, Combination</term>
<term>Dyskinesia</term>
<term>Dyskinesia, Drug-Induced (etiology)</term>
<term>Dyskinesia, Drug-Induced (prevention & control)</term>
<term>Experimental disease</term>
<term>Female</term>
<term>Levodopa</term>
<term>Levodopa (administration & dosage)</term>
<term>Levodopa (metabolism)</term>
<term>Levodopa (pharmacology)</term>
<term>Locomotion (drug effects)</term>
<term>L‐dopa</term>
<term>MPTP</term>
<term>Male</term>
<term>Nitriles</term>
<term>Parkinson disease</term>
<term>Parkinsonian Disorders (prevention & control)</term>
<term>Posology</term>
<term>Primates</term>
<term>Pulse Therapy, Drug (methods)</term>
<term>Substantia Nigra (drug effects)</term>
<term>Time Factors</term>
<term>Treatment efficiency</term>
<term>dyskinesia</term>
<term>entacapone</term>
<term>primates</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Carbidopa</term>
<term>Catechols</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Carbidopa</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Carbidopa</term>
<term>Catechols</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Locomotion</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Pulse Therapy, Drug</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
<term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Callithrix</term>
<term>Dose-Response Relationship, Drug</term>
<term>Drug Synergism</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Male</term>
<term>Nitriles</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animal</term>
<term>Antiparkinsonien</term>
<term>Chimiothérapie</term>
<term>Dose</term>
<term>Dyskinésie</term>
<term>Efficacité traitement</term>
<term>Lévodopa</term>
<term>Parkinson maladie</term>
<term>Pathologie expérimentale</term>
<term>Posologie</term>
<term>Primates</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Levodopa (L‐dopa) consistently primes basal ganglia for the appearance of dyskinesia in parkinsonian patients and 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine hydrochloride (MPTP) ‐treated primates. This finding may reflect its relatively short duration of effects resulting in pulsatile stimulation of postsynaptic dopamine receptors in the striatum. We have compared the relationship between L‐dopa dose and frequency of administration on dyskinesia initiation in drug‐naïve, MPTP‐treated common marmosets. We have also studied the effect of increased brain exposure to pulsatile administration by combining a low‐dose of L‐dopa with the peripheral catechol‐O‐methyltransferase inhibitor (COMT‐I), entacapone. Pulsatile administration of a low (dose range, 5.0–7.5 mg/kg p.o.) or a high (12.5 mg/kg) dose of L‐dopa plus carbidopa b.i.d. produced a dose‐related reversal of motor deficits. Repeated administration of low and high doses of L‐dopa for 26 days to drug‐naïve, MPTP‐treated animals also caused a dose‐related induction of peak‐dose dyskinesia. Repeated administration of high‐dose L‐dopa b.i.d. compared to once daily caused a frequency‐related improvement of motor symptoms, resulting in a more rapid and initially more intense appearance of peak‐dose dyskinesia. Administration of low‐dose L‐dopa b.i.d. for 26 days in combination with entacapone enhanced the increase in locomotor activity and reversal of disability produced by L‐dopa alone, but with no obvious change in duration of L‐dopa's effect. However, combining entacapone with L‐dopa resulted in the more rapid appearance of dyskinesia, which was initially more severe than occurred with L‐dopa alone. Importantly, increasing pulsatile exposure of brain to L‐dopa by preventing its peripheral breakdown also increases dyskinesia induction. © 2003 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
</region>
<settlement><li>Londres</li>
</settlement>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Smith, Lance A" sort="Smith, Lance A" uniqKey="Smith L" first="Lance A." last="Smith">Lance A. Smith</name>
</region>
<name sortKey="Hansard, Matthew J" sort="Hansard, Matthew J" uniqKey="Hansard M" first="Matthew J." last="Hansard">Matthew J. Hansard</name>
<name sortKey="Jackson, Michael J" sort="Jackson, Michael J" uniqKey="Jackson M" first="Michael J." last="Jackson">Michael J. Jackson</name>
<name sortKey="Jenner, Peter" sort="Jenner, Peter" uniqKey="Jenner P" first="Peter" last="Jenner">Peter Jenner</name>
<name sortKey="Maratos, Eleni" sort="Maratos, Eleni" uniqKey="Maratos E" first="Eleni" last="Maratos">Eleni Maratos</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004108 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004108 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:B332C5624656CEA1219E695C498CAAE735CA56EC |texte= Effect of pulsatile administration of levodopa on dyskinesia induction in drug‐naïve MPTP‐treated common marmosets: Effect of dose, frequency of administration, and brain exposure }}
This area was generated with Dilib version V0.6.23. |